作者
Rodrigo Santa Cruz Guindalini, Yonglan Zheng, Hiroyuki Abe, Kristen Whitaker, Toshio F Yoshimatsu, Tom Walsh, David Schacht, Kirti Kulkarni, Deepa Sheth, Marion S Verp, Angela R Bradbury, Jane Churpek, Elias Obeid, Jeffrey Mueller, Galina Khramtsova, Fang Liu, Akila Raoul, Hongyuan Cao, Iris L Romero, Susan Hong, Robert Livingston, Nora Jaskowiak, Xiaoming Wang, Marcio Debiasi, Colin C Pritchard, Mary-Claire King, Gregory Karczmar, Gillian M Newstead, Dezheng Huo, Olufunmilayo I Olopade
发表日期
2019/3/15
期刊
Clinical Cancer Research
卷号
25
期号
6
页码范围
1786-1794
出版商
American Association for Cancer Research
简介
Purpose
To establish a cohort of high-risk women undergoing intensive surveillance for breast cancer.
Experimental Design: We performed dynamic contrast-enhanced MRI every 6 months in conjunction with annual mammography (MG). Eligible participants had a cumulative lifetime breast cancer risk ≥20% and/or tested positive for a pathogenic mutation in a known breast cancer susceptibility gene.
Results
Between 2004 and 2016, we prospectively enrolled 295 women, including 157 mutation carriers (75 BRCA1, 61 BRCA2); participants' mean age at entry was 43.3 years. Seventeen cancers were later diagnosed: 4 ductal carcinoma in situ (DCIS) and 13 early-stage invasive breast cancers. Fifteen cancers occurred in mutation carriers (11 BRCA1, 3 BRCA2, 1 CDH1). Median size of the invasive cancers was 0.61 cm. No patients had lymph node metastasis at …
学术搜索中的文章
RSC Guindalini, Y Zheng, H Abe, K Whitaker… - Clinical Cancer Research, 2019