作者
M Golzarand, S Shab-Bidar, G Koochakpoor, K Djafarian
发表日期
2016/8/1
来源
Nutrition, Metabolism and Cardiovascular Diseases
卷号
26
期号
8
页码范围
663-673
出版商
Elsevier
简介
Background and aims
Previous randomized clinical trials (RCTs) of the effects of vitamin D3 supplementation (VD3S) on blood pressure have generated inconsistent results. We evaluated the effect of VD3S on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in a meta-analysis.
Data synthesis
Literature searches of PubMed, Scopus, Ovid, and Google scholar for publications in English were conducted up to April 2015. RCTs that assessed the effect of VD3S on SBP and DBP were selected.
Conclusions
A total of 30 RCTs with 41 arms including 4744 participants were included. The mean duration of the studies was 5.6 ± 4.0 months, and doses of VD3S varied between 200 and 12,000 IU/day. VD3S had no effect on SBP (−0.68 mmHg, 95%CI: −2.19 to 0.84), and DBP (−0.57 mmHg, 95%CI: −1.36 to 0.22). Subgroup analysis revealed that daily vitamin D3 therapy at a dose of >800 IU/day for <6 months …
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M Golzarand, S Shab-Bidar, G Koochakpoor… - Nutrition, Metabolism and Cardiovascular Diseases, 2016