作者
Matthew J Grigg, Timothy William, Bridget E Barber, Giri S Rajahram, Jayaram Menon, Emma Schimann, Kim Piera, Christopher S Wilkes, Kaajal Patel, Arjun Chandna, Christopher J Drakeley, Tsin W Yeo, Nicholas M Anstey
发表日期
2018/7/18
期刊
Clinical infectious diseases
卷号
67
期号
3
页码范围
350-359
出版商
Oxford University Press
简介
Background
Plasmodium knowlesi is increasingly reported in Southeast Asia, but prospective studies of its clinical spectrum in children and comparison with autochthonous human-only Plasmodium species are lacking.
Methods
Over 3.5 years, we prospectively assessed patients of any age with molecularly–confirmed Plasmodium monoinfection presenting to 3 district hospitals in Sabah, Malaysia.
Results
Of 481 knowlesi, 172 vivax, and 96 falciparum malaria cases enrolled, 44 (9%), 71 (41%), and 31 (32%) children aged ≤12 years. Median parasitemia was lower in knowlesi malaria (2480/μL [interquartile range, 538–8481/μL]) than in falciparum (9600/μL; P < .001) and vivax malaria. In P. knowlesi, World Health Organization–defined anemia was present in 82% (95% confidence interval [CI], 67%–92%) of children vs 36% (95% CI, 31%–41%) of …
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MJ Grigg, T William, BE Barber, GS Rajahram, J Menon… - Clinical infectious diseases, 2018