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We previously reported that intraperitoneal (i.p.) injection (20 mg/kg) of (−)-epigallocatechin-3-gallate (EGCG), the main polyphenolic constituent of green tea, decreased β-amyloid (Aβ) levels and plaques via promotion of the non-amyloidogenic α-secretase proteolytic pathway in “Swedish” mutant amyloid precursor protein overexpressing (APPsw, Tg) mice. Here, we find that EGCG administered orally in drinking water (50 mg/kg) similarly reduces Aβ deposition in these mice. Following a six month treatment of an 8 month old cohort, immunohistochemical analysis of coronal sections reveals that plaque burdens were reduced in the cingulate cortex, hippocampus, and entorhinal cortex by 54%, 43%, and 51%, respectively. Congo red plaque burdens were decreased in the cingulate cortex, hippocampus, and entorhinal cortex by 53%, 53%, and 58%, respectively as well. ELISA of brain homogenates of the treatment …