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Hypertrophic scar and keloid are two types of fibroproliferative conditions that result from excessive extracellular matrix production. The underlying pathological mechanism is not entirely clear. Activation of the renin‐angiotensin system (RAS) is associated with fibrosis in various organs. RAS components including angiotensin II (Ang II), angiotensin AT₁ and AT₂ receptors, and angiotensin‐converting enzyme (ACE) are expressed in the skin and act independently from the plasma RAS. AT₁ receptors, which are usually the dominating receptor subtype, promote fibrosis and scar formation, while AT₂ receptors inhibit the aforementioned AT₁ receptor‐coupled effects. Elevated angiotensin II (Ang II) levels acting on the AT₁ receptor contribute to skin scar formation through increased expression of inflammatory factors such as interleukin‐6 (IL‐6), angiogenic factors such as vascular endothelial growth factor (VEGF) and …