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Colorectal cancer (CRC) is the third leading cause of cancer death in the United States, resulting in an average of 50,000 deaths per year. Surgery and combination chemotherapy comprise current treatment strategies. However, curative options are limited if surgery and chemotherapy are unsuccessful. Several studies have indicated that CRC aggressiveness and potential for metastatic spread are associated with the acquisition of stem cell like properties. The Notch‐1 receptor and its cognate signaling pathway is well known for controlling cell fate decisions and stem‐cell phenotypes. Alterations in Notch receptors and Notch signaling has been reported for some colon cancers. Herein, we examine a potential role for Notch‐1 signaling in CRC. In CRC patient samples, Notch‐1 expression was increased in colon tumor tissue as compared with normal colon tissue. Retroviral transduction of constitutively active …