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Electronic cigarettes (e‐cigs) are the most commonly used tobacco product by teens and young adults. The aim of the present study was to determine the potential effects of e‐cig vapor exposure on cardiac function in adolescent mice.

Four‐week‐old FVB/NJ male mice were separated into three exposure groups: 1) e‐cig exposure with nicotine (EC(+)) (20.2 mg nicotine/1 mL 50:50 propylene glycol:vegetable glycerin), 2) e‐cig exposure without nicotine (EC(‐)), or 3) filtered air exposure (FA) (HEPA filter), and exposed for three months. A puff profile consisting of one 70‐mL e‐cig vapor puff per minute of exposure was administered for 4 h/day, 5 days/week over the course of three months, and filtered air was administered continuously throughout the 4‐hour periods. Cotinine concentration in the serum of mice from either group was determined using a cotinine ELISA …