作者
Tobias Kurth, J Michael Gaziano, Klaus Berger, Carlos S Kase, Kathryn M Rexrode, Nancy R Cook, Julie E Buring, JoAnn E Manson
发表日期
2002/12/9
期刊
Archives of internal medicine
卷号
162
期号
22
页码范围
2557-2562
出版商
American Medical Association
简介
Background
Although obesity is an established risk factor for coronary heart disease, its role as a risk factor for stroke remains controversial.
Methods
Prospective cohort study among 21 414 US male physicians participating in the Physicians' Health Study. Incidence of total, ischemic, and hemorrhagic stroke was measured by self-report and confirmed by medical record review. We used Cox proportional hazards models to evaluate the association of body mass index (BMI), calculated as self-reported weight in kilograms divided by the square of the height in meters, with risk of total, ischemic, and hemorrhagic stroke.
Results
During 12.5 years of follow-up, 747 strokes (631 ischemic, 104 hemorrhagic, and 12 undefined) occurred. Compared with participants with BMIs less than 23, those with BMIs of 30 or greater had an adjusted relative risk of 2.00 (95% confidence interval [CI], 1.48-2.71) for total stroke, 1.95 (95% CI …
引用总数
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