作者
Daniel I Chasman, Markus Schürks, Verneri Anttila, Boukje de Vries, Ulf Schminke, Lenore J Launer, Gisela M Terwindt, Arn MJM van den Maagdenberg, Konstanze Fendrich, Henry Völzke, Florian Ernst, Lyn R Griffiths, Julie E Buring, Mikko Kallela, Tobias Freilinger, Christian Kubisch, Paul M Ridker, Aarno Palotie, Michel D Ferrari, Wolfgang Hoffmann, Robert YL Zee, Tobias Kurth
发表日期
2011/7
期刊
Nature genetics
卷号
43
期号
7
页码范围
695-698
出版商
Nature Publishing Group
简介
Migraine is a common, heterogeneous and heritable neurological disorder. Its pathophysiology is incompletely understood, and its genetic influences at the population level are unknown. In a population-based genome-wide analysis including 5,122 migraineurs and 18,108 non-migraineurs, rs2651899 (1p36.32, PRDM16), rs10166942 (2q37.1, TRPM8) and rs11172113 (12q13.3, LRP1) were among the top seven associations (P < 5 × 10−6) with migraine. These SNPs were significant in a meta-analysis among three replication cohorts and met genome-wide significance in a meta-analysis combining the discovery and replication cohorts (rs2651899, odds ratio (OR) = 1.11, P = 3.8 × 10−9; rs10166942, OR = 0.85, P = 5.5 × 10−12; and rs11172113, OR = 0.90, P = 4.3 × 10−9). The associations at rs2651899 and rs10166942 were specific for migraine compared with non-migraine headache. None of the three SNP …
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DI Chasman, M Schürks, V Anttila, B de Vries… - Nature genetics, 2011