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The activity of two selected isothiocyanates (ITCs), allylisothiocyanate (AITC) and 2-phenylethy-lisothiocyanate (PEITC) was evaluated on the prevention and control of biofilms formed by Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Listeria monocytogenes. In addition, the effect of ITCs was also tested on planktonic cell susceptibility, bacterial motility and adhesion. Biofilm prevention and control were tested using a microtiter plate assay and the effect of ITCs was assessed on biofilm mass and metabolic activity. The minimum bactericidal concentration for E. coli and P. aeruginosa was 1000 μg mL⁻¹ (AITC) and >1000 μg mL⁻¹ (PEITC), for S. aureus and L. monocytogenes was >1000 μg mL⁻¹ (for both ITCs). AITC caused total inhibition of swimming (P. aeruginosa) and swarming (E. coli) motilities. PEITC caused total inhibition of swimming (E. coli, P. aeruginosa and L. monocytogenes …