作者
Perline A Demange, Margherita Malanchini, Travis T Mallard, Pietro Biroli, Simon R Cox, Andrew D Grotzinger, Elliot M Tucker-Drob, Abdel Abdellaoui, Louise Arseneault, Elsje Van Bergen, Dorret I Boomsma, Avshalom Caspi, David L Corcoran, Benjamin W Domingue, Kathleen Mullan Harris, Hill F Ip, Colter Mitchell, Terrie E Moffitt, Richie Poulton, Joseph A Prinz, Karen Sugden, Jasmin Wertz, Benjamin S Williams, Eveline L De Zeeuw, Daniel W Belsky, K Paige Harden, Michel G Nivard
发表日期
2021/1
期刊
Nature genetics
卷号
53
期号
1
页码范围
35-44
出版商
Nature Publishing Group US
简介
Little is known about the genetic architecture of traits affecting educational attainment other than cognitive ability. We used genomic structural equation modeling and prior genome-wide association studies (GWASs) of educational attainment (n = 1,131,881) and cognitive test performance (n = 257,841) to estimate SNP associations with educational attainment variation that is independent of cognitive ability. We identified 157 genome-wide-significant loci and a polygenic architecture accounting for 57% of genetic variance in educational attainment. Noncognitive genetics were enriched in the same brain tissues and cell types as cognitive performance, but showed different associations with gray-matter brain volumes. Noncognitive genetics were further distinguished by associations with personality traits, less risky behavior and increased risk for certain psychiatric disorders. For socioeconomic success and …
学术搜索中的文章
PA Demange, M Malanchini, TT Mallard, P Biroli… - Nature genetics, 2021