作者
Liang Dai, Yuguang Mu, Lars Nordenskiöld, Johan RC van der Maarel
发表日期
2008/3/18
期刊
Physical review letters
卷号
100
期号
11
页码范围
118301
出版商
American Physical Society
简介
All atom molecular dynamics simulations with explicit water were done to study the interaction between two parallel double-stranded DNA molecules in the presence of the multivalent counterions putrescine (2+), spermidine (3+), spermine (4+) and cobalt hexamine (3+). The inter-DNA interaction potential is obtained with the umbrella sampling technique. The attractive force is rationalized in terms of the formation of ion bridges, ie, multivalent ions which are simultaneously bound to the two opposing DNA molecules. The lifetime of the ion bridges is short on the order of a few nanoseconds.
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