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Prominent healthcare organizations have called upon the academic and health communities to utilize interprofessional education (IPE) and collaboration to meet the changing needs of patients worldwide. Two student-led initiatives have overcome the various barriers that have historically impeded IPE and have embraced the call to improve the health of local and international underserved patients. This short report describes these two organizations, the International Health Service Collaborative at the University of South Florida and the Inter Health Professionals Alliance at Virginia Commonwealth University, and aims to encourage emerging health professional students and educators to embrace student-led IPE.