作者
Premika SW Boedhoe, Lianne Schmaal, Yoshinari Abe, Stephanie H Ameis, Paul D Arnold, Marcelo C Batistuzzo, Francesco Benedetti, Jan C Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Yuqi Cheng, Kang Ik K Cho, Sara Dallaspezia, Damiaan Denys, Kate D Fitzgerald, Jean-Paul Fouche, Mònica Giménez, Patricia Gruner, Gregory L Hanna, Derrek P Hibar, Marcelo Q Hoexter, Hao Hu, Chaim Huyser, Keisuke Ikari, Neda Jahanshad, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Jun Soo Kwon, Luisa Lazaro, Yanni Liu, Christine Lochner, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, José M Menchón, Luciano Minuzzi, Takashi Nakamae, Tomohiro Nakao, Janardhanan C Narayanaswamy, Fabrizio Piras, Federica Piras, Christopher Pittenger, YC Janardhan Reddy, Joao R Sato, H Blair Simpson, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Michael C Stevens, Philip R Szeszko, David F Tolin, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Guido A Van Wingen, Jian Xu, Xiufeng Xu, Je-Yeon Yun, Qing Zhao, Enigma Ocd Working Group, Paul M Thompson, Dan J Stein, Odile A van den Heuvel, members of the ENIGMA OCD Working Group
发表日期
2017/1/1
期刊
American Journal of Psychiatry
卷号
174
期号
1
页码范围
60-69
出版商
American Psychiatric Association
简介
Objective
Structural brain imaging studies in obsessive-compulsive disorder (OCD) have produced inconsistent findings. This may be partially due to limited statistical power from relatively small samples and clinical heterogeneity related to variation in illness profile and developmental stage. To address these limitations, the authors conducted meta- and mega-analyses of data from OCD sites worldwide.
Method
T1 images from 1,830 OCD patients and 1,759 control subjects were analyzed, using coordinated and standardized processing, to identify subcortical brain volumes that differ between OCD patients and healthy subjects. The authors performed a meta-analysis on the mean of the left and right hemisphere measures of each subcortical structure, and they performed a mega-analysis by pooling these volumetric measurements from each site. The authors additionally examined potential modulating effects of …
学术搜索中的文章
PSW Boedhoe, L Schmaal, Y Abe, SH Ameis… - American Journal of Psychiatry, 2017