作者
Jesús Pujol, Carles Soriano-Mas, Pino Alonso, Narcís Cardoner, José M Menchón, Joan Deus, Julio Vallejo
发表日期
2004/7/1
期刊
Archives of general psychiatry
卷号
61
期号
7
页码范围
720-730
出版商
American Medical Association
简介
Background
Recent technical developments have made it feasible to comprehensively assess brain anatomy in psychiatric populations.
Objective
To describe the structural brain alterations detected in the magnetic resonance images of a large series of patients with obsessive-compulsive disorder (OCD) using imaging procedures that allow the evaluation of volume changes throughout the brain.
Design
Case-control study.
Setting
Referral OCD unit in a tertiary hospital.
Participants
A consecutive sample of 72 outpatients with OCD and 72 age- and sex-matched control subjects.
Interventions
Three-dimensional sequences were obtained in all participants. A statistical parametric mapping approach was used to delineate possible anatomical alterations in the entire brain. To preserve volumetric information, voxel values were modulated by the Jacobian determinants (volume change measurement) derived from spatial …
引用总数
学术搜索中的文章
J Pujol, C Soriano-Mas, P Alonso, N Cardoner… - Archives of general psychiatry, 2004