作者
Maxim S Petrov, Hjalmar C van Santvoort, Marc GH Besselink, Geert JMG van der Heijden, John A Windsor, Hein G Gooszen
发表日期
2008/11/17
来源
Archives of Surgery
卷号
143
期号
11
页码范围
1111-1117
出版商
American Medical Association
简介
Objective
To compare the effect of enteral vs parenteral nutrition in patients with severe acute pancreatitis for clinically relevant outcomes.
Data Sources
A computerized literature search was performed in the MEDLINE, EMBASE, and Cochrane databases for articles published from January 1, 1966, until December 15, 2006.
Study Selection
From 253 publications screened, 5 randomized controlled trials comparing enteral and parenteral nutrition in patients with predicted severe acute pancreatitis met the inclusion criteria.
Data Extraction
Information on study design, patient characteristics, and acute pancreatitis outcomes were independently extracted by two of us using a standardized protocol.
Data Synthesis
A meta-analysis of randomized controlled trials was performed using a random-effects model. Enteral feeding reduced the risk of infectious complications (relative risk, 0.47; 95% confidence interval, 0.28-0.77;P < …
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