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Twenty extracts including ten EtOH and ten CH₂Cl₂ from different parts of nine African medicinal plants used in Congolese traditional medicine for the treatment of malaria, were submitted to a pharmacological test in order to evaluate their effect on P.falciparum growth in vitro. Of these plant species, 14 (70%) extracts including EtOH and CH₂Cl₂ from Cassiaoccidentalis leaves, Cryptolepissanguinolenta root bark, Euphorbiahirta whole plant, Garciniakola stem bark and seeds, Morindalucida leaves and Phyllanthusniruri whole plant produced more than 60% inhibition of the parasite growth in vitro at a test concentration of 6 μg/ml. Extracts from E.hirta, C.sanguinolenta and M.morindoides showed a significant chemosuppression of parasitaemia in mice infected with P.bergheiberghei at orally given doses of 100–400 mg/kg per day.