查看文章

Purpose: To evaluate the incidence of chronic cicatrizing conjunctivitis (CCC) and its associated risk factors in the context of chronic ocular graft-vs-host disease (coGVHD).

Methods: A retrospective chart review of individuals diagnosed with coGVHD following hematopoietic stem cell transplantation (HSCT) between January 1992 and June 2021 was performed. Data regarding baseline demographic characteristics (age, sex, ethnicity, race) and systemic risk factors (eg, dyslipidemia, hypertension, diabetes mellitus) were collected. Incidence of cicatricial conjunctivitis was estimated with Kaplan-Meier survival analysis. A Cox regression model was used to assess the contribution of demographic and systemic variables to the development of CCC.

Results: 182 eyes of 173 individuals were included (53.8±14.3 years old; 58.9% male). 43 eyes of 42 individuals presented with features suggestive of CCC 60.4±50.6 …