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This work was supported by the Medical Research Council [grant numbers MC_PC19070 and MR/V028375/1, and MR/N013867/1 to Miss Miller] and the Wellcome Trust [grant number 206602 to Professor Aldridge]. The study also received Facebook advertising credit to support a pilot social media recruitment campaign on 18th August 2020. Research at the UCL Great Ormond Street Institute of Child Health is supported by the NIHR GOSH Biomedical Research Centre [grant number IS-BRC-1215-20012]. The other authors received no additional funding. The sponsors of the study had no role in conducting this analysis or drafting this manuscript.