作者
Tal Dvir, Brian P Timko, Mark D Brigham, Shreesh R Naik, Sandeep S Karajanagi, Oren Levy, Hongwei Jin, Kevin K Parker, Robert Langer, Daniel S Kohane
发表日期
2011/11
期刊
Nature nanotechnology
卷号
6
期号
11
页码范围
720-725
出版商
Nature Publishing Group UK
简介
Engineered cardiac patches for treating damaged heart tissues after a heart attack are normally produced by seeding heart cells within three-dimensional porous biomaterial scaffolds,,. These biomaterials, which are usually made of either biological polymers such as alginate or synthetic polymers such as poly(lactic acid) (PLA), help cells organize into functioning tissues, but poor conductivity of these materials limits the ability of the patch to contract strongly as a unit. Here, we show that incorporating gold nanowires within alginate scaffolds can bridge the electrically resistant pore walls of alginate and improve electrical communication between adjacent cardiac cells. Tissues grown on these composite matrices were thicker and better aligned than those grown on pristine alginate and when electrically stimulated, the cells in these tissues contracted synchronously. Furthermore, higher levels of the proteins involved …
引用总数
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学术搜索中的文章
T Dvir, BP Timko, MD Brigham, SR Naik, SS Karajanagi… - Nature nanotechnology, 2011