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Senna alata L. crude stem bark extract on all the tested dermatophytes was 5.0 mg/mL. The result showed that the crude extract of S. alata L stem bark was fungicidal for all tested dermatophytes at concentration of 10.00 and 5.00 mg/mL except E. floccosum which was only fungicidal at concentration of 10.00 mg/mL. The crude extract of S. alata L. stem bark screening showed vary degree of activities against all the tested dermatophytes. Phytochemical analysis revealed the presence of important secondary metabolites (tannins, steroids, alkaloids, anthraquinones, terpenes, carbohydrates and saponins) in the plant thus indicating the therapeutic potentials of the plant. It is concluded that S. alata L. stem bark could be a potential source of active antimicrobial agents, and a detailed assessment of its in vivo potencies and toxicological profile is therefore advocated.