作者
Pranav Chettri, Ana M Calvo, Jeffrey W Cary, Sourabh Dhingra, Yanan Guo, Rebecca L McDougal, Rosie E Bradshaw
发表日期
2012/2/1
期刊
Fungal Genetics and Biology
卷号
49
期号
2
页码范围
141-151
出版商
Academic Press
简介
Fungi possess genetic systems to regulate the expression of genes involved in complex processes such as development and secondary metabolite biosynthesis. The product of the velvet gene veA, first identified and characterized in Aspergillus nidulans, is a key player in the regulation of both of these processes. Since its discovery and characterization in many Aspergillus species, VeA has been found to have similar functions in other fungi, including the Dothideomycete Mycosphaerella graminicola. Another Dothideomycete, Dothistroma septosporum, is a pine needle pathogen that produces dothistromin, a polyketide toxin very closely related to aflatoxin (AF) and sterigmatocystin (ST) synthesized by Aspergillus spp. Dothistromin is unusual in that, unlike most other secondary metabolites, it is produced mainly during the early exponential growth phase in culture. It was therefore of interest to determine whether the …
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P Chettri, AM Calvo, JW Cary, S Dhingra, Y Guo… - Fungal Genetics and Biology, 2012