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BACKGROUND

Mounting evidence highlighting the benefits of hemostatic resuscitation has led to a renewed interest in whole blood (WB) and reconstituted WB (RWB). However, few data exist to characterize the clotting profiles of these variants. This study characterizes banked WB variants and RWB in standard 1: 1: 1 and 2: 1: 1 transfusion ratios of packed red blood cells, fresh frozen plasma, and platelets (PLTs). We hypothesized that the global hemostatic profile of 1: 1: 1 RWB is superior to 2: 1: 1 RWB and that PLT-modified WB (MWB) is superior to 1: 1: 1 RWB.

METHODS

Twenty-three units of packed red blood cells, fresh frozen plasma, and PLTs were obtained from the regional blood collection center and mixed to create 23 1: 1: 1 and 23 2: 1: 1 RWB units. Freshly donated WB units were obtained and used to create 11 of each nonmodified WB (NMWB)(room temperature and cooled) and MWB (room …