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BACKGROUND

Although obese patients have high thrombosis rates following injury, the role of obesity in coagulation after trauma remains unknown. We hypothesized that body mass index (BMI) is independently associated with increased measures of hypercoagulability longitudinally after injury.

METHODS

Data were prospectively collected for 377 consecutive highest-level trauma activation patients with a BMI of 18.5 kg/m 2 or greater. Standard coagulation measures, citrated kaolin and functional fibrinogen thromboelastography, as well as clotting factors were measured at 0 hour to 120 hours. BMI categories were defined as normal weight (18.5–24.99 kg/m 2), overweight (25–29.99 kg/m 2), and obese (≥ 30 kg/m 2).

RESULTS

The 377 patients were mostly male (81%) and had blunt injury (61%), with a median BMI of 25.8 kg/m 2. Of the patients, 42% were normal weight (median BMI, 22.5 kg/m 2). There were no …