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Objective of the proposal was to establish rapid, economical, and robust liquid chromatographic procedure to perform quality control of a pharmaceutical preparation containing amlodipine and celecoxib using an experimental design. The proposed new high-performance liquid chromatography (HPLC) procedure involves isocratic separation using sodium phosphate buffer (pH 5.6): acetonitrile: methanol in a ratio 30:55:15 (v/v) as the mobile phase on a Zorbax C18 (150 mm) reverse-phase (RP)-HPLC column. The analysis was performed at 25°C, using a flow rate of 1.2 mL/minute. The column elutes were detected at 239 nm and etoricoxib has been selected as an internal standard (IS). The calibration curve exhibited good linearity in the range of 5–30 µg/mL of amlodipine and 50–500 µg/mL of celecoxib with a good correlation coefficient (r² > 0.999). The precision and accuracy were presented in terms of …