作者
Beatriz Tavira, Eliecer Coto, Armando Torres, Carmen Díaz-Corte, Beatriz Díaz-Molina, Francisco Ortega, Manuel Arias, Juan M Díaz, Rafael Selgas, Carlos López-Larrea, Marta Ruiz-Ortega, Alberto Ortiz, Elena González, Josep M Campistol, Victoria Alvarez, Pharmacogenetics of tacrolimus REDINREN study group
发表日期
2012/3/1
期刊
Molecular Genetics and metabolism
卷号
105
期号
3
页码范围
525-527
出版商
Academic Press
简介
KCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K). AA+AG genotypes were significantly associated with NODAT-risk (p=0.004; OR=2.10). The reported effect of this KCNJ11 polymorphism on insulin release by beta cells could explain this association.
学术搜索中的文章
B Tavira, E Coto, A Torres, C Díaz-Corte, B Díaz-Molina… - Molecular Genetics and metabolism, 2012