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Background

Few studies have examined how the endocannabinoid (eCB) system is impacted by stress following traumatic injury. The current study examined serum levels of circulating eCBs N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) in response to isometric exercise (hand grip) challenge in recently traumatically injured adults. We explored if exercise-induced changes in eCBs varied with posttraumatic stress disorder (PTSD) or depression symptoms.

Methods

Participants included mostly racial or ethnic minority adults who had recently been traumatically injured (eg, by a motor vehicle crash). We employed a hand-grip challenge at 3-months (n= 65) and 6-months (n= 67) post injury, with blood draws before and after.

Results

Levels of eCBs pre-exercise challenge were markedly elevated, compared to the literature, at both timepoints (MAEA=. 67; M2-AG= 2.97). At 3-months, the percent …