作者
Maxsim L Gibiansky, Jacinta C Conrad, Fan Jin, Vernita D Gordon, Dominick A Motto, Margie A Mathewson, Wiktor G Stopka, Daria C Zelasko, Joshua D Shrout, Gerard CL Wong
发表日期
2010/10/8
期刊
Science
卷号
330
期号
6001
页码范围
197-197
出版商
American Association for the Advancement of Science
简介
Bacterial biofilms are structured multicellular communities involved in a broad range of infections. Knowing how free-swimming bacteria adapt their motility mechanisms near surfaces is crucial for understanding the transition between planktonic and biofilm phenotypes. By translating microscopy movies into searchable databases of bacterial behavior, we identified fundamental type IV pili–driven mechanisms for Pseudomonas aeruginosa surface motility involved in distinct foraging strategies. Bacteria stood upright and “walked” with trajectories optimized for two-dimensional surface exploration. Vertical orientation facilitated surface detachment and could influence biofilm morphology.
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