作者
Dale C Hesdorffer, Emma KT Benn, Emilia Bagiella, Douglas Nordli, John Pellock, Veronica Hinton, Shlomo Shinnar, FEBSTAT Study Team
发表日期
2011/7
期刊
Annals of neurology
卷号
70
期号
1
页码范围
93-100
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Objective
In prior studies of febrile seizures (FSs), prolonged FSs were defined, absent empirical evidence, as lasting 10 or 15 minutes or more. We assessed the distribution of FS duration in a cohort with first FSs, and the association between FS duration and baseline characteristics of the children.
Methods
We calculated the observed cumulative probability, S(t), that a FS would last at least t minutes, S(t) = exp(−t/τ). Data were also fit using a model obtained as the sum of 2 exponential distributions (S[t] = αexp[−t1] + [1 − α]exp[−t2]). After assessing the best fit, the cutoff defining long FS was determined. Logistic regression was used to examine associations between long FSs and baseline characteristics, behavior, and development.
Results
In 158 children with a first FS, median duration was 4.0 minutes. Duration of FS was best fit by a 2‐component mixture exponential model. Using this model, we identified 1 …
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