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Previous studies have employed different experimental approaches to enhance visual function in adults with amblyopia including perceptual learning, videogame play, and dichoptic training. Here, we evaluated the efficacy of a novel dichoptic action videogame combining all three approaches. This experimental intervention was compared to a conventional, yet unstudied method of supervised occlusion while watching movies.

Adults with unilateral amblyopia were assigned to either play the dichoptic action game (n = 23; ‘game’ group), or to watch movies monocularly while the fellow eye was patched (n = 15; ‘movies’ group) for a total of 40 hours.

Following training, visual acuity (VA) improved on average by ≈0.14 logMAR (≈28%) in the game group, with improvements noted in both anisometropic and strabismic patients. This improvement is similar to that obtained following perceptual learning, video game play …