作者
Mark O Huising, René JM Stet, Huub FJ Savelkoul, BM Lidy Verburg-van Kemenade
发表日期
2004/5/3
来源
Developmental & Comparative Immunology
卷号
28
期号
5
页码范围
395-413
出版商
Pergamon
简介
The cytokine network is an important homeostatic system with potent activities in immune surveillance, growth, developmental and repair processes. Although interleukin-1β (IL-1β) is considered a pivotal pro-inflammatory cytokine, merely focussing on its inflammatory role would be too narrow an approach. Elucidation of the human, the mouse and the Fugu rubripes (pufferfish) genome now enables a more comprehensive overview of this cytokine family and its receptors in several vertebrate classes. Phylogenetic analyses of the IL-1 family members, comprising over 80 sequences of various fish, amphibian, avian and mammalian species, reveal that for only a few mammalian IL-1 family members unambiguous orthologues have been found in fish, indicating a recent origin of some of the mammalian IL-1 family members. Interestingly, the Fugu genome did reveal teleost orthologues for IL-18 and its putative receptor …
引用总数
学术搜索中的文章
MO Huising, RJM Stet, HFJ Savelkoul… - Developmental & Comparative Immunology, 2004