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Monosodium-iodoacetate (MIA)-induced animal model of osteoarthritis (OA) is under-utilised despite having many inherent advantages. At present, there is lack of studies that directly compare the degenerative changes induced by MIA with the surgical osteoarthritis induction method and human osteoarthritis, which would further verify a greater use of this model. Therefore, we compared the histological, biochemical and biomechanical characteristics in rat model using MIA against the anterior cruciate ligament transection (ACLT) and human cartilage with clinically established osteoarthritis. The right knees of Sprague-Dawley rats were subjected to either MIA or ACLT (n= 18 in each group). Six rats were used as controls. Human cartilage samples were collected and compared from patients clinically diagnosed with (n= 7) and without osteoarthritis (n= 3). Histological, biochemical (Glycosaminoglycans/total protein …