作者
Evan J Zasowski, Matteo Bassetti, Francesco Blasi, Herman Goossens, Jordi Rello, Giovanni Sotgiu, Lara Tavoschi, Mick R Arber, Rachael McCool, Jacoby V Patterson, Christopher M Longshaw, Sara Lopes, Davide Manissero, Sean T Nguyen, Keiko Tone, Stefano Aliberti
发表日期
2020/9/1
来源
Chest
卷号
158
期号
3
页码范围
929-938
出版商
Elsevier
简介
Background
Patients with severe bacterial infections often experience delay in receiving appropriate treatment. Consolidated evidence of the impact of delayed appropriate treatment is needed to guide treatment and improve outcomes.
Research Question
What is the impact of delayed appropriate antibacterial therapy on clinical outcomes in patients with severe bacterial infections?
Study Design and Methods
Literature searches of MEDLINE and Embase, conducted on July 24, 2018, identified studies published after 2007 reporting the impact of delayed appropriate therapy on clinical outcomes for hospitalized adult patients with bacterial infections. Where appropriate, results were pooled and analyzed with delayed therapy modeled three ways: delay vs no delay in receiving appropriate therapy; duration of delay; and inappropriate vs appropriate initial therapy. This article reports meta-analyses on the effect of delay …
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