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To evaluate the effectiveness of the AutoPap System in detecting abnormal and normal cervical smears when used in a primary screening/quality control mode, as compared with currently established laboratory practices. Slides were obtained prospectively and were initially processed in the routine fashion with cytotechnologist screening followed by 10% random quality control rescreening. Slides were then processed on the AutoPap System and allocated into the following groups:(1) approximately 25% of the lowest-ranking slides were placed in the laboratory’s archives as within normal limits;(2) the remaining approximately 75% of slides were subjected to manual screening. Approximately 15% of the highestranking slides in this group underwent quality control rescreening. For each slide needing manual screening, the cytotechnologist was supplied with a report giving the ranking …