作者
Marloes van der Leest, Erik Cornel, Bas Israel, Rianne Hendriks, Anwar R Padhani, Martijn Hoogenboom, Patrik Zamecnik, Dirk Bakker, Anglita Yanti Setiasti, Jeroen Veltman, Huib van den Hout, Hans van der Lelij, Inge van Oort, Sjoerd Klaver, Frans Debruyne, Michiel Sedelaar, Gerjon Hannink, Maroeska Rovers, Christina Hulsbergen-van de Kaa, Jelle O Barentsz
发表日期
2019/4/1
期刊
European urology
卷号
75
期号
4
页码范围
570-578
出版商
Elsevier
简介
Background
There is growing interest to implement multiparametric magnetic resonance imaging (mpMRI) and MR-guided biopsy (MRGB) for biopsy-naïve men with suspected prostate cancer.
Objective
Primary objective was to compare and evaluate an MRI pathway and a transrectal ultrasound-guided biopsy (TRUSGB) pathway in biopsy-naïve men with prostate-specific antigen levels of ≥3 ng/ml.
Design, setting, and population
A prospective, multicenter, powered, comparative effectiveness study included 626 biopsy-naïve patients (from February 2015 to February 2018).
Intervention
All patients underwent prebiopsy mpMRI followed by systematic TRUSGB. Men with suspicious lesions on mpMRI also underwent MRGB prior to TRUSGB. MRGB was performed using the in-bore approach.
Outcome measurements and statistical analysis
Clinically significant prostate cancer (csPCa) was defined as grade group ≥2 …
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