作者
Wilhelmina G Melsen, Maroeska M Rovers, Rolf HH Groenwold, Dennis CJJ Bergmans, Christophe Camus, Torsten T Bauer, Ernst W Hanisch, Bengt Klarin, Mirelle Koeman, Wolfgang A Krueger, Jean-Claude Lacherade, Leonardo Lorente, Ziad A Memish, Lee E Morrow, Giuseppe Nardi, Christianne A van Nieuwenhoven, Grant E O'Keefe, George Nakos, Frank A Scannapieco, Philippe Seguin, Thomas Staudinger, Arzu Topeli, Miquel Ferrer, Marc JM Bonten
发表日期
2013/8/1
期刊
The Lancet infectious diseases
卷号
13
期号
8
页码范围
665-671
出版商
Elsevier
简介
Background
Estimating attributable mortality of ventilator-associated pneumonia has been hampered by confounding factors, small sample sizes, and the difficulty of doing relevant subgroup analyses. We estimated the attributable mortality using the individual original patient data of published randomised trials of ventilator-associated pneumonia prevention.
Methods
We identified relevant studies through systematic review. We analysed individual patient data in a one-stage meta-analytical approach (in which we defined attributable mortality as the ratio between the relative risk reductions [RRR] of mortality and ventilator-associated pneumonia) and in competing risk analyses. Predefined subgroups included surgical, trauma, and medical patients, and patients with different categories of severity of illness scores.
Findings
Individual patient data were available for 6284 patients from 24 trials. The overall attributable …
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WG Melsen, MM Rovers, RHH Groenwold… - The Lancet infectious diseases, 2013