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The transcription factor NF-κB has served as a standard for inducible transcription factors for more than 20 years. The numerous stimuli that activate NF-κB, and the large number of genes regulated by NF-κB, ensure that this transcription factor is still the subject of intense research. Here, we attempt to synthesize some of the basic principles that have emerged from studies of NF-κB, and we aim to generate a more unified view of NF-κB regulation.