作者
Rebecca G Baker, Matthew S Hayden, Sankar Ghosh
发表日期
2011/1/5
来源
Cell metabolism
卷号
13
期号
1
页码范围
11-22
出版商
Elsevier
简介
Metabolic disorders including obesity, type 2 diabetes, and atherosclerosis have been viewed historically as lipid storage disorders brought about by overnutrition. It is now widely appreciated that chronic low-grade inflammation plays a key role in the initiation, propagation, and development of metabolic diseases. Consistent with its central role in coordinating inflammatory responses, numerous recent studies have implicated the transcription factor NF-κB in the development of such diseases, thereby further establishing inflammation as a critical factor in their etiology and offering hope for the development of new therapeutic approaches for their treatment.
引用总数
学术搜索中的文章
RG Baker, MS Hayden, S Ghosh - Cell metabolism, 2011