作者
Yanchun Peng, Alexander J Mentzer, Guihai Liu, Xuan Yao, Zixi Yin, Danning Dong, Wanwisa Dejnirattisai, Timothy Rostron, Piyada Supasa, Chang Liu, César López-Camacho, Jose Slon-Campos, Yuguang Zhao, David I Stuart, Guido C Paesen, Jonathan M Grimes, Alfred A Antson, Oliver W Bayfield, Dorothy EDP Hawkins, De-Sheng Ker, Beibei Wang, Lance Turtle, Krishanthi Subramaniam, Paul Thomson, Ping Zhang, Christina Dold, Jeremy Ratcliff, Peter Simmonds, Thushan de Silva, Paul Sopp, Dannielle Wellington, Ushani Rajapaksa, Yi-Ling Chen, Mariolina Salio, Giorgio Napolitani, Wayne Paes, Persephone Borrow, Benedikt M Kessler, Jeremy W Fry, Nikolai F Schwabe, Malcolm G Semple, J Kenneth Baillie, Shona C Moore, Peter JM Openshaw, M Azim Ansari, Susanna Dunachie, Eleanor Barnes, John Frater, Georgina Kerr, Philip Goulder, Teresa Lockett, Robert Levin, Yonghong Zhang, Ronghua Jing, Ling-Pei Ho, ISARIC4C Investigators Kenneth Baillie J. 18 Klenerman Paul 4 5 20 Mentzer Alexander J. 3 4 5 Moore Shona C. 12 Openshaw Peter JM 19 Semple Malcolm G. 12 17 Stuart David I. 2 3 4 9 Turtle Lance 11 12, Richard J Cornall, Christopher P Conlon, Paul Klenerman, Gavin R Screaton, Juthathip Mongkolsapaya, Andrew McMichael, Julian C Knight, Graham Ogg, Tao Dong
发表日期
2020/11
期刊
Nature immunology
卷号
21
期号
11
页码范围
1336-1345
出版商
Nature Publishing Group US
简介
The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We studied T cell memory in 42 patients following recovery from COVID-19 (28 with mild disease and 14 with severe disease) and 16 unexposed donors, using interferon-γ-based assays with peptides spanning SARS-CoV-2 except ORF1. The breadth and magnitude of T cell responses were significantly higher in severe as compared with mild cases. Total and spike-specific T cell responses correlated with spike-specific antibody responses. We identified 41 peptides containing CD4+ and/or CD8+ epitopes, including six immunodominant regions. Six optimized CD8+ epitopes were defined, with peptide–MHC pentamer-positive cells displaying the central and effector memory phenotype. In mild cases, higher proportions of SARS-CoV-2-specific CD8+ T cells …
学术搜索中的文章
Y Peng, AJ Mentzer, G Liu, X Yao, Z Yin, D Dong… - Nature immunology, 2020
T Dong, W Dejnirattisai, T Rostron, P Supasa, C Liu… - Nat Imunol, 2020