作者
Pawel Grzechnik, Sue Mei Tan-Wong, Nick J Proudfoot
发表日期
2014/7/1
来源
Trends in biochemical sciences
卷号
39
期号
7
页码范围
319-327
出版商
Elsevier
简介
Bidirectional promoters are a common feature of many eukaryotic organisms from yeast to humans. RNA Polymerase II that is recruited to this type of promoter can start transcribing in either direction using alternative DNA strands as the template. Such promiscuous transcription can lead to the synthesis of unwanted transcripts that may have negative effects on gene expression. Recent studies have identified transcription termination and gene looping as critical players in the enforcement of promoter directionality. Interestingly, both mechanisms share key components. Here, we focus on recent findings relating to the transcriptional output of bidirectional promoters.
学术搜索中的文章
P Grzechnik, SM Tan-Wong, NJ Proudfoot - Trends in biochemical sciences, 2014