作者
Chrishan J Nalliah, James R Bell, Antonia JA Raaijmakers, Helen M Waddell, Simon P Wells, Gabriel B Bernasochi, Magdalene K Montgomery, Simon Binny, Troy Watts, Subodh B Joshi, Elaine Lui, Choon Boon Sim, Marco Larobina, Michael O’Keefe, John Goldblatt, Alistair Royse, Geoffrey Lee, Enzo R Porrello, Matthew J Watt, Peter M Kistler, Prashanthan Sanders, Lea MD Delbridge, Jonathan M Kalman
发表日期
2020/9/8
期刊
Journal of the American College of Cardiology
卷号
76
期号
10
页码范围
1197-1211
出版商
American College of Cardiology Foundation
简介
Background
Clinical studies have reported that epicardial adipose tissue (EpAT) accumulation associates with the progression of atrial fibrillation (AF) pathology and adversely affects AF management. The role of local cardiac EpAT deposition in disease progression is unclear, and the electrophysiological, cellular, and molecular mechanisms involved remain poorly defined.
Objectives
The purpose of this study was to identify the underlying mechanisms by which EpAT influences the atrial substrate for AF.
Methods
Patients without AF undergoing coronary artery bypass surgery were recruited. Computed tomography and high-density epicardial electrophysiological mapping of the anterior right atrium were utilized to quantify EpAT volumes and to assess association with the electrophysiological substrate in situ. Excised right atrial appendages were analyzed histologically to characterize EpAT infiltration, fibrosis …
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CJ Nalliah, JR Bell, AJA Raaijmakers, HM Waddell… - Journal of the American College of Cardiology, 2020