作者
Tim Lahm, Ivor S Douglas, Stephen L Archer, Harm J Bogaard, Naomi C Chesler, Francois Haddad, Anna R Hemnes, Steven M Kawut, Jeffrey A Kline, Todd M Kolb, Stephen C Mathai, Olaf Mercier, Evangelos D Michelakis, Robert Naeije, Rubin M Tuder, Corey E Ventetuolo, Antoine Vieillard-Baron, Norbert F Voelkel, Anton Vonk-Noordegraaf, Paul M Hassoun
发表日期
2018/8/15
来源
American journal of respiratory and critical care medicine
卷号
198
期号
4
页码范围
e15-e43
出版商
American Thoracic Society
简介
Background: Right ventricular (RV) adaptation to acute and chronic pulmonary hypertensive syndromes is a significant determinant of short- and long-term outcomes. Although remarkable progress has been made in the understanding of RV function and failure since the meeting of the NIH Working Group on Cellular and Molecular Mechanisms of Right Heart Failure in 2005, significant gaps remain at many levels in the understanding of cellular and molecular mechanisms of RV responses to pressure and volume overload, in the validation of diagnostic modalities, and in the development of evidence-based therapies.
Methods: A multidisciplinary working group of 20 international experts from the American Thoracic Society Assemblies on Pulmonary Circulation and Critical Care, as well as external content experts, reviewed the literature, identified important knowledge gaps, and provided recommendations.
Results …
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T Lahm, IS Douglas, SL Archer, HJ Bogaard… - American journal of respiratory and critical care …, 2018