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This article presents a general methodology for processing non-stationary signals for the purpose of classification and localization. The methodology combines methods adapted from three complementary areas: time-frequency signal analysis, multichannel signal analysis and image processing. The latter three combine in a new methodology referred to as multichannel time-frequency image processing which is applied to the problem of classifying electroencephalogram (EEG) abnormalities in both adults and newborns. A combination of signal related features and image related features are used by merging key instantaneous frequency descriptors which characterize the signal non-stationarities. The results obtained show that, firstly, the features based on time-frequency image processing techniques such as image segmentation, improve the performance of EEG abnormalities detection in the …