作者
Francesco Bussu, Michela Sali, Roberto Gallus, Valerio Gaetano Vellone, Gian Franco Zannoni, Rosa Autorino, Nicola Dinapoli, Rosaria Santangelo, Rosa Martucci, Cristina Graziani, Francesco Micciche, Giovanni Almadori, Jacopo Galli, Giovanni Delogu, Maurizio Sanguinetti, Guido Rindi, Vincenzo Valentini, Gaetano Paludetti
发表日期
2013/3
期刊
British journal of cancer
卷号
108
期号
5
页码范围
1157-1162
出版商
Nature Publishing Group
简介
Background:
Human papillomavirus 16 infection has been proven to be associated with oropharyngeal squamous cell carcinomas (SCCs) and is probably the main reason of the reported increase in the incidence. The role of high-risk (HR) HPV for carcinogenesis of other sites in the head and neck awaits confirmation. With the aim to evaluate the prevalence of HPV infection and the reliability of different diagnostic tools in SCCs of different sites, 109 consecutive untreated head and neck SCCs were enroled, and fresh tumour samples collected.
Methods:
Human papillomavirus DNA was detected by Digene Hybrid Capture 2 (HC2). Human papillomavirus E6 and E7 mRNA were detected by NucliSENS EasyQ HPVv1. P16 expression was evaluated by immunohistochemistry.
Results:
In all, 12.84% of cases were infected by HR genotypes and 1.84% by low-risk genotypes. Human papillomavirus 16 accounted for 87 …
学术搜索中的文章
F Bussu, M Sali, R Gallus, VG Vellone, GF Zannoni… - British journal of cancer, 2013