作者
Nicole M Revie, Kali R Iyer, Nicole Robbins, Leah E Cowen
发表日期
2018/10/1
来源
Current opinion in microbiology
卷号
45
页码范围
70-76
出版商
Elsevier Current Trends
简介
Highlights
- Our limited arsenal of antifungals is threatened by drug-resistant fungal pathogens.
- Inherent resistance is when all strains of a species show antifungal resistance.
- Target alteration and drug efflux are canonical adaptive resistance mechanisms.
- Stress responses are important mediators of resistance to diverse antifungals.
- Agricultural use of antifungals may drive the development of resistance.
Microorganisms have a remarkable capacity to evolve resistance to antimicrobial agents, threatening the efficacy of the limited arsenal of antimicrobials and becoming a dire public health crisis. This is of particular concern for fungal pathogens, which cause devastating invasive infections with treatment options limited to only three major classes of antifungal drugs. The paucity of antifungals with clinical utility is in part due to close evolutionary relationships between these eukaryotic pathogens and their human hosts …
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NM Revie, KR Iyer, N Robbins, LE Cowen - Current opinion in microbiology, 2018
