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This symposium presents results of the Swiss SiRENE study on acute, short-and long-term effects of transportation noise exposure on annoyance, sleep disturbances and cardiometabolic risks. SiRENE aims at identifying those noise exposure patterns that most strongly affect individuals and thus may ultimately result in long-term health consequences. The study includes a representative population survey on noise annoyance and sleep disturbance, an experimental study in the sleep laboratory applying contrived noise exposure scenarios, and the analysis of the SAPALDIA Biobank and Swiss National Cohort (SNC) data where cardiometabolic morbidity and cardiovascular mortality risks due to noise exposure as well as disease pathways were addressed. Further, a nationwide assessment of road, railway and aircraft noise exposure was conducted to estimate noise levels and the degree of noise intermittence for the whole Swiss population. Key findings of all aspects are presented as an example for how mutual combination of human experimental and observational epidemiological research contributes to a better understanding of the role of disturbed sleep, diurnal variation of noise and extent of intermittence for acute, short-and long-term noise effects on cardiometabolic outcomes.