作者
Constance D Lehman, Claudine Isaacs, Mitchell D Schnall, Etta D Pisano, Susan M Ascher, Paul T Weatherall, David A Bluemke, Deborah J Bowen, P Kelly Marcom, Deborah K Armstrong, Susan M Domchek, Gail Tomlinson, Steven J Skates, Constantine Gatsonis
发表日期
2007/8
期刊
Radiology
卷号
244
期号
2
页码范围
381-388
出版商
Radiological Society of North America
简介
Purpose: To prospectively determine cancer yield, callback and biopsy rates, and positive predictive value (PPV) of mammography, magnetic resonance (MR) imaging, and ultrasonography (US) in women at high risk for breast cancer.
Materials and Methods: The study was approved by the institutional review board and was HIPAA compliant, and informed consent was obtained. We conducted a prospective pilot study of screening mammography, MR, and US in asymptomatic women 25 years of age or older who were genetically at high risk, defined as BRCA1/BRCA2 carriers or with at least a 20% probability of carrying a BRCA1/BRCA2 mutation. All imaging modalities were performed within 90 days of each other. Data were analyzed by using exact confidence intervals (CIs) and the McNemar test.
Results: A total of 195 women were enrolled in this study over a 6-month period, and 171 completed all study …
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CD Lehman, C Isaacs, MD Schnall, ED Pisano… - Radiology, 2007