作者
Miguel Regueiro, Brian G Feagan, Bin Zou, Jewel Johanns, Marion A Blank, Marc Chevrier, Scott Plevy, John Popp, Freddy J Cornillie, Milan Lukas, Silvio Danese, Paolo Gionchetti, Stephen B Hanauer, Walter Reinisch, William J Sandborn, Dario Sorrentino, Paul Rutgeerts, H Debinski, T Florin, D Hetzel, I Lawrance, G Radford-Smith, A Sloss, D Sorrentino, S Gassner, T Haas, G Reicht, W Reinisch, M Strasser, H Vogelsang, P Bossuyt, O DeWit, G D'Haens, D Franchimont, E Louis, S Vermeire, CN Bernstein, R Bourdages, N Chiba, SS Dhalla, BG Feagan, RN Fedorak, JR Lachance, R Panaccione, M Ropeleski, B Singh Salh, M Lukas, JF Colombel, M Allez, P Desreumaux, JL Dupas, JC Grimaud, X Hebuterne, D Laharie, E Lerebours, L Peyrin-Biroulet, JM Reimund, S Viennot, F Zerbib, C Antoni, R Atreya, DC Baumgart, C Berg, U Boecker, G Bramkamp, C Bünning, R Ehehalt, S Howaldt, T Kucharzik, HG Lamprecht, J Mudter, JC Preiss, S Schreiber, U Seidler, I Altorjay, J Banai, PL Lakatos, M Varga, A Vincze, I Avni-Biron, S Fishman, GM Fraser, E Goldin, D Rachmilewitz, V Annese, S Ardizzone, L Biancone, F Bossa, S Danese, Walter Fries, P Gionchetti, G Maconi, Giovanni Terrosu, P Usai, GR D'Haens, RB Gearry, J Hill, DS Rowbotham, M Schultz, RS Stubbs, D Wallace, RS Walmsley, J Wyeth, E Malecka-Panas, L Paradowski, J Regula, IP Beales, S Campbell, AB Hawthorne, M Parkes, SP Travis, JP Achkar, BW Behm, SJ Bickston, KJ Brown, MV Chiorean, WJS DeVilliers, DE Elliott, D Grunkmeier, JW Hamilton, SB Hanauer, JS Hanson, R Hardi, DJ Helper, H Herfarth, PDR Higgins, WH Holderman, R Kottoor, MD Kreines, BI Leman, X Li, EV Loftus Jr, M Noar, I Oikonomou, J Onken, KA Peterson, RP Phillips, CW Randall, M Ricci, T Ritter, DT Rubin, M Safdi, WJ Sandborn, L Sauberman, E Scherl, RP Schwarz, S Sedghi, I Shafran, CA Sninsky, I Stein
发表日期
2016/6/1
期刊
Gastroenterology
卷号
150
期号
7
页码范围
1568-1578
出版商
WB Saunders
简介
Background & Aims
Most patients with Crohn’s disease (CD) eventually require an intestinal resection. However, CD frequently recurs after resection. We performed a randomized trial to compare the ability of infliximab vs placebo to prevent CD recurrence.
Methods
We evaluated the efficacy of infliximab in preventing postoperative recurrence of CD in 297 patients at 104 sites worldwide from November 2010 through May 2012. All study patients had undergone ileocolonic resection within 45 days before randomization. Patients were randomly assigned (1:1) to groups given infliximab (5 mg/kg) or placebo every 8 weeks for 200 weeks. The primary end point was clinical recurrence, defined as a composite outcome consisting of a CD Activity Index score >200 and a ≥70-point increase from baseline, and endoscopic recurrence (Rutgeerts score ≥i2, determined by a central reader) or development of a new or re …
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M Regueiro, BG Feagan, B Zou, J Johanns, MA Blank… - Gastroenterology, 2016