作者
Beth K Boyarsky, Waheedul Haque, Mark R Rouleau, Robert MA Hirschfeld
发表日期
1999
期刊
Depression and anxiety
卷号
9
期号
4
页码范围
175-179
出版商
John Wiley & Sons, Inc.
简介
Objectives—One‐third of patients with untreated depression have sexual difficulties manifested by decreased libido, erectile dysfunction or delayed ejaculation. This dysfunction may be exacerbated by stimulation of post‐synaptic serotonin 5HT2 receptors, a side‐effect of most widely‐used antidepressant medications, especially the selective serotonin reuptake inhibitors (SSRIs). Mirtazapine is an atypical antidepressant with a2 adrenergic antagonist and serotonin 5‐HT2 and 5‐HT3 receptor‐blocking activity. In theory, it should not worsen and perhaps may improve sexual function. This pilot study investigated sexual functioning and antidepressant activity in depressed patients taking mirtazapine. Experimental design—Twenty‐five (F = 18, M = 7) sexually active adult outpatients with a DSM‐IV‐diagnosis of major depressive episode entered a 12‐week, flexible‐dosing, open‐label pilot study. The Arizona Sexual …
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BK Boyarsky, W Haque, MR Rouleau, RMA Hirschfeld - Depression and anxiety, 1999