作者
Maria J Ribeiro, Joana F Sacramento, Teresa Gallego‐Martin, Elena Olea, Bernardete F Melo, Maria P Guarino, Sara Yubero, Ana Obeso, Silvia V Conde
发表日期
2018/8
期刊
The Journal of physiology
卷号
596
期号
15
页码范围
3187-3199
简介
Key points
- Leptin plays a role in the control of breathing, acting mainly on central nervous system; however, leptin receptors have been recently shown to be expressed in the carotid body (CB), and this finding suggests a physiological role for leptin in the regulation of CB function.
- Leptin increases minute ventilation in both basal and hypoxic conditions in rats. It increases the frequency of carotid sinus nerve discharge in basal conditions, as well as the release of adenosine from the CB. However, in a metabolic syndrome animal model, the effects of leptin in ventilatory control, carotid sinus nerve activity and adenosine release by the CB are blunted.
- Although leptin may be involved in triggering CB overactivation in initial stages of obesity and dysmetabolism, resistance to leptin signalling and blunting of responses develops in metabolic syndrome animal models.
Abstract
Leptin plays a role in the control of …
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MJ Ribeiro, JF Sacramento, T Gallego‐Martin, E Olea… - The Journal of physiology, 2018
